Total synthesis of the antifungal dilactones UK-2A and UK-3A: The determination of their relative and absolute configurations, analog synthesis and antifungal …

M Shimano, N Kamei, T Shibata, K Inoguchi, N Itoh…

Index: Shimano, Masanao; Kamei, Noriyuki; Shibata, Tetsuo; Inoguchi, Kiyoshi; Itoh, Nobuko; Ikari, Takashi; Senda, Hisato Tetrahedron, 1998 , vol. 54, # 42 p. 12745 - 12774

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Citation Number: 18

Abstract

The synthesis of the antifungal dilactones, UK-2A and UK-3A, is described. In addition to providing a workable synthetic route to these potent antifungal antibiotics, this has allowed us to determine the assignment of the relative and absolute configurations in the nine- membered ring. Furthermore, UK-2A analogs were also synthesized and evaluated their antifungal activities and cytotoxic activities along with UK-2A,(2R, 3R, 4S, 7R)-UK-2A, UK- ...