Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl n??(3, 4, 4′, 5??tetramethoxybenzhydryl) pyroglutamate (hei 81) by using n??acyl iminium …

…, G Sanz, F Camus, B Norberg, F Durant…

Index: Bourry, Anne; Pitard, Franck; Rigo, Benoit; Sanz, Gerard; Camus, Fabrice; Norberg, Bernadette; Durant, Francois; Couturier, Daniel Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 1 p. 109 - 118

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Citation Number: 6

Abstract

Abstract Some ways to use the N-acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N-(3, 4, 4′, 5-tetramethoxybenzhydryl) pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3-(3, 4, 5-trimethoxyphenyl) dihydropy-rrolo [1, 2-c] oxazole-1, 5- dione).

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