Journal of the American Chemical Society

Iron-Facilitated Direct Oxidative C− H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles

C Qin, N Jiao

Index: Qin, Chong; Jiao, Ning Journal of the American Chemical Society, 2010 ,  vol. 132,  # 45  p. 15893 - 15895

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Citation Number: 110

Abstract

This paper describes the first direct approach to alkenyl nitriles from allylarenes or alkenes facilitated by an inexpensive homogeneous iron catalyst. Three C− H bond cleavages occur under the mild conditions during this process. Mechanistic studies indicate that the cleavage of the allyl C (sp3)− H bond is involved in the rate-determining step. This observation may provide an opportunity to achieve C (sp3)− H functionalization catalyzed by an iron ...