Pyridonecarboxylic acids as antibacterial agents. Synthesis and antibacterial activity of 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-1, 8- …

…, T Miyamoto, A Minamida, Y Nishimura…

Index: Egawa; Miyamoto; Minamida; Nishimura; Okada; Uno; Matsumoto Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1543 - 1548

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Citation Number: 63

Abstract

As exemplified by pipemidic acid (1), 2 we showed first that a piperazinyl group was of much importance for the improvement of antibacterial activity and pharmacokinetic properties of a class of pyridonecarboxylic acid antibacterial agents. During the last few years, several analogues having both fluoro and piperazinyl groups in their mole-