Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non??replicating persistence

…, K Biswas, P Narayanasamy, M Kurosu…

Index: Kurosu, Michio; Narayanasamy, Prabagaran; Biswas, Kallolmay; Dhiman, Rakesh; Crick, Dean C. Journal of Medicinal Chemistry, 2007 ,  vol. 50,  # 17  p. 3973 - 3975

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Citation Number: 66

Abstract

Summary Understanding the basis of bacterial persistence in latent infections is critical for eradication of tuberculosis. Analysis of Mycobacterium tuberculosis mRNA expression in an in vitro model of non-replicating persistence indicated that the bacilli require electron transport chain components and ATP synthesis for survival. Additionally, low μM concentrations of aminoalkoxydiphenylmethane derivatives inhibited both the aerobic ...