Rapid synthesis of 11 C-labeled FK506 for positron emission tomography
Y Murakami, A Kuroda, K Osoda, S Nishimura
Index: Murakami, Yoshihiro; Kuroda, Akio; Osoda, Kazuhiko; Nishimura, Shintaro Tetrahedron Letters, 2003 , vol. 44, # 4 p. 641 - 644
Full Text: HTML
Citation Number: 9
Abstract
The present study describes a rapid synthesis method for labeled [11C] FK506 for positron emission tomography (PET). A one-pot reaction from [11C] CH3I, involving a Wittig reaction as the key carbon carbon bond formation was developed. The chemical process was accomplished using a designed, fully automated synthetic apparatus, and an injectable solution of [11C] FK506 was obtained in only 34 min from [11C] CH3I. The decay- ...
Related Articles:
[Nakatsuka, Masashi; Ragan, John A.; Sammakia, Tarek; Smith, David B.; Uehling, David E.; Schreiber, Stuart L. Journal of the American Chemical Society, 1990 , vol. 112, # 14 p. 5583 - 5601]
[Journal of the American Chemical Society, , vol. 112, # 14 p. 5583 - 5601]
[Ireland, Robert E.; Liu, Longbin; Roper, Thomas D.; Gleason, James L. Tetrahedron, 1997 , vol. 53, # 39 p. 13257 - 13284]
[Journal of Natural Products, , vol. 76, # 6 p. 1091 - 1098]
[Tetrahedron, , vol. 53, # 39 p. 13257 - 13284]