Design, synthesis and in vitro antimicrobial activity of novel phenylbenzamido-aminothiazole-based azasterol mimics

…, OP Chourasia, MP Jogi, AR Podile, RS Perali

Index: Yadlapalli, Rama Krishna; Chourasia; Jogi, Madhu Prakash; Podile, Appa Rao; Perali, Ramu Sridhar Medicinal Chemistry Research, 2013 ,  vol. 22,  # 6  p. 2975 - 2983

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Abstract

Abstract Phenylbenzamide framework as a mimic of the azasterol structure was investigated by synthesizing 4-phenylbenzamido-2-aminothiazole 4, and evaluating its MIC against Escherichia coli, Enterobacter cloacae, Bacillus licheniformis and Mycobacterium tuberculosis (MTB) H 37 Rv as well as antifungal activity against three test phytopathogenic fungi. Further, the bioisosterism strategy was implemented to synthesize a series of azo- ...