Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model

…, N Minowa, H Kuzuhara, S Nishiyama

Index: Sasaki, Kazue; Minowa, Nobuto; Kuzuhara, Hiroyuki; Nishiyama, Shoji Bioorganic and Medicinal Chemistry, 2005 ,  vol. 13,  # 16  p. 4900 - 4911

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Citation Number: 12

Abstract

To shed light on the structure–activity relationship, various soyasapogenol B derivatives were synthesized and evaluated for preventive effects on liver injury in the concanavalin A (Con A)-induced hepatitis model in mice. Con A injection into mice induces some pathophysiology of human liver disease such as autoimmune or viral hepatitis. Two hydroxyl groups on the A ring of soyasapogenol B are required for amelioration of liver damage. ...