Quinoline formation via a modified Combes reaction: examination of kinetics, substituent effects, and mechanistic pathways

JC Sloop

Index: Sloop, Joseph C. Journal of Physical Organic Chemistry, 2009 , vol. 22, # 2 p. 110 - 117

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Citation Number: 17

Abstract

Abstract This is the first reported investigation of the Combes condensation employing 19F NMR spectroscopy to monitor intermediate consumption and product formation rates. The reaction was found to be first order in both the diketone and aniline. Product ...