A highly regioselective Friedländer reaction mediated by lanthanum chloride

Y Chen, J Huang, TL Hwang, TJ Li, S Cui, J Chan…

Index: Chen, Ying; Huang, Jinkun; Hwang, Tsang-Lin; Li; Cui, Sheng; Chan, Johann; Bio, Matthew Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3237 - 3241

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Citation Number: 17

Abstract

Quinoline and its derivatives are among the most important synthetic or natural heterocycles with interesting biological activities showing anti-malarial, anti-inflammatory, anti-bacterial, and anti-asthmatic properties. 1 As a result, the quinoline scaffolds have spurred the development of a great deal of synthetic methodologies. Among those variations, the Friedländer reaction 2 is one of the simplest, straightforward, and most widely used approaches. 3 This ...