Trichothecene degradation studies. 2. Synthesis of [13-14C] anguidine

WR Roush, S Russo-Rodriguez

Index: Roush, William R.; Russo-Rodriguez, Sandra Journal of Organic Chemistry, 1987 ,  vol. 52,  # 4  p. 598 - 603

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Citation Number: 15

Abstract

An efficient degradation and resynthesis of anguidine that pivots around norketone 4 is described. The sequence from anguidine to anguidine via 4 proceeds in 12 steps with an overall yield of 30%. This work has permitted for the first time the preparation of an enantiomerically pure, high specific activity I4C-labeled epoxytrichothecene mycotoxin required for biological investigations. The radiolabel was introduced by the reaction of 4 ...