European Journal of Organic Chemistry

From planning to optimization: total synthesis of valerenic acid and some bioactive derivatives

J Ramharter, J Mulzer

Index: Ramharter, Juergen; Mulzer, Johann European Journal of Organic Chemistry, 2012 ,  # 10  p. 2041 - 2053

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Citation Number: 6

Abstract

Abstract A detailed study of the total synthesis of valerenic acid, a well known GABA A receptor subtype modulator, is described. Both successful as well as unsuccessful attempts towards the synthesis of the title compound are presented, including four different strategies to synthesize one of the key intermediates. The first two strategies are based on epoxides provided from the chiral pool, whereas the last two approaches rest on stereocontrolled ...