Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in …

FC Huang, TS Shoupe, CJ Lin, TDY Lee…

Index: Huang, Fu-Chih; Shoupe, T. Scott; Lin, Clara J.; Lee, Thomas D. Y.; Chan, Wan-Kit; et al. Journal of Medicinal Chemistry, 1989 ,  vol. 32,  # 8  p. 1836 - 1842

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Citation Number: 29

Abstract

The synthesis of a series of novel substituted hydroxamates has been described along with their profile of inhibitory activity against 5-lipoxygenase, 12-lipoxygenase, and cyclooxygenase enzymes. The structure-activity relationship suggests that future molecules could be designed to specifically inhibit one or more of these enzymes since there were definite differences in structure-activity relationships for these different enzymes. A ...