A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase

N Balasubramanian, PJ Brown, JD Catt…

Index: Balasubramanian, N.; Brown, P. J.; Catt, J. D.; Han, W. T.; Parker, R. A.; et al. Journal of Medicinal Chemistry, 1989 ,  vol. 32,  # 9  p. 2038 - 2041

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Citation Number: 24

Abstract

Journal of Medicinal Chemistry, 1989, Vol. 32, No. 9 2039 models of mevinolin and compactin suggested that an increase in steric bulk at that position would be desireable. These considerations led us to the choice of alkylated tetrazoles as target structures. In this preliminary report, we would like to disclose that one of these compounds, 1, is a promising drug candidate for further development. Compound 1 was originally synthesized by ...