Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors

WG Huang, YY Jiang, Q Li, J Li, JY Li, W Lu, JC Cai

Index: Huang, Wei Gang; Jiang, Ying Yan; Li, Qian; Li, Jia; Li, Jing Ya; Lu, Wei; Cai, Jun Chao Tetrahedron, 2005 , vol. 61, # 7 p. 1863 - 1870

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Citation Number: 39

Abstract

(±)-Cryptotanshinone and its simplified analogues were synthesized via SmI2 promoted radical cyclization to construct the furan ring. Analogues and were identified as effective inhibitors of dual specificity protein phosphatase CDC25B which is a key enzyme for cell cycle progression, and they also inhibited growth in A-549 human lung cancer cell line.