Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor

G Wess, K Kesseler, E Baader, W Bartmann, G Beck…

Index: Wess; Kesseler; Baader; Bartmann; Beck; Bergmann; Jendralla; Bock; Holzstein; Kleine; Schnierer Tetrahedron Letters, 1990 ,  vol. 31,  # 18  p. 2545 - 2548

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Citation Number: 77

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... HR 780 (1) a new HMG-CoA reductase inhibitor has been synthesized stereoselectively starting from L-malic acid. Wittig olefination employing phosphonium halides, phosphonates and phosphane oxides have been investigated. ... HR 780 has been synthesized stereospecifically ...