Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo [1, 2-b] pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor

S Huang, R Lin, Y Yu, Y Lu, PJ Connolly, G Chiu…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1243 - 1245

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Citation Number: 84

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Though all the three unsubstituted carbons (C-4, C-6, C-7) of the indazole ring could potentially be replaced with nitrogen, only the chemistry for pyrazolo[1,2-b]pyridine synthesis was successfully developed. ...

Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region–Abelson (Bcr-Abl) …

[Ren, Xiaomei; Pan, Xiaofen; Zhang, Zhang; Wang, Deping; Lu, Xiaoyun; Li, Yupeng; Wen, Donghai; Long, Huoyou; Luo, Jinfeng; Feng, Yubing; Zhuang, Xiaoxi; Zhang, Fengxiang; Liu, Jianqi; Leng, Fang; Lang, Xingfen; Bai, Yang; She, Miaoqin; Tu, Zhengchao; Pan, Jingxuan; Ding, Ke Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 879 - 894]

Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo [1, 2-b] pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor

Abstract

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