A novel short and efficient synthetic route to the antimalarial agent FR900098 and derivatives

J Perruchon, R Ortmann, M Schlitzer

Index: Perruchon, Johann; Ortmann, Regina; Schlitzer, Martin Synthesis, 2007 , # 22 p. 3553 - 3557

Full Text: HTML

Citation Number: 9

Abstract

Abstract We report here a new operationally simple, economical, and environmentally friendly multicomponent approach for a one-pot synthesis of the antimalarial agent FR900098. The reaction allows the fast construction of the compound from simple and commercially available substrates and reagents and is also applicable to the synthesis of modified derivatives of FR900098.