Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents

…, KL Dhar, SC Puri, AK Saxena, M Shanmugavel…

Index: Bhat; Dhar; Puri; Saxena; Shanmugavel; Qazi Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 3177 - 3180

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Citation Number: 276

Abstract

A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i, j, n, 4i, j, n and 4s, showed marked activity. Compounds 4j, n and 4s were found to be the most promising in this study. SAR is also discussed.