Solid??Phase Synthesis of (Poly) phosphorylated Nucleosides and Conjugates

VC Tonn, C Meier

Index: Tonn, Viktoria Caroline; Meier, Chris Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9832 - 9842

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Citation Number: 21

Abstract

Abstract Succinyl-cycloSal-phosphate triesters of ribo-and 2′-deoxyribonucleosides were attached to aminomethyl polystyrene as an insoluble solid support and reacted with phosphate-containing nucleophiles yielding nucleoside di-and triphosphates, nucleoside diphosphate sugars, and dinucleoside polyphosphates in high purity after cleavage from the solid support. Here, reactive cycloSal-phosphate triesters were used as immobilized ...