Gold (I)-catalyzed 6-endo hydroxycyclization of 7-substituted-1, 6-enynes

…, MA Fernández-Rodríguez, R Sanz

Index: Sanjuan, Ana M.; Martinez, Alberto; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Sanz, Roberto Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2242 - 2249

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Citation Number: 6

Abstract

Abstract The cyclization of o-(alkynyl)-3-(methylbut-2-enyl) benzenes, 1, 6-enynes having a condensed aromatic ring at C3–C4 positions, has been studied under the catalysis of cationic gold (I) complexes. The selective 6-endo-dig mode of cyclization observed for the 7- substituted substrates in the presence of water or methanol giving rise to hydroxy (methoxy)- functionalized dihydronaphthalene derivatives is highly remarkable in the context of the ...