Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells

…, A Kurume, Y Oda, S Nakamura, M Yamashita…

Index: Nakashima, Souichi; Matsuda, Hisashi; Kurume, Ai; Oda, Yoshimi; Nakamura, Seikou; Yamashita, Masayuki; Yoshikawa, Masayuki Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2994 - 2997

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Citation Number: 34

Abstract

Cucurbitane-type triterpenes, cucurbitacins B and E, were reported to exhibit cytotoxic effects in several cell lines mediated by JAK/STAT3 signaling. However, neither compound inhibited phosphorylation of STAT3 in human leukemia (U937) cells at low concentrations. We therefore synthesized a biotin-linked cucurbitacin E to isolate target proteins based on affinity for the molecule. As a result, cofilin, which regulates the depolymerization of actin, ...