Convenient synthesis of carvedilol utilizing 3-(9H-carbazol-4-yloxy)-1-chloropropan-2-yl phenyl carbonate as a key intermediate

…, V Rajesh, S Parveen, G Madhusudhan

Index: Kumar, B. Anand; Ashrafuddin; Rajesh; Parveen, Sadhika; Madhusudhan Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 5 p. 780 - 784

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Citation Number: 2

Abstract

Abstract: Convenient synthesis of pharmaceutically important moiety Carvedilol, 1 (β- adrenergic blocking agent) has been reported utilizing 3-(9H-carbazol-4-yloxy)-1- chloropropan-2-yl phenyl carbonate 8 as a key intermediate. The synthetic scheme involves the reaction of intermediate 8 with 2-(2-methoxy phenoxy) ethanamine 5 by using N, N- Dimethyl-4-aminopyridine (DMAP) in N, N-dimethylformamide (DMF) which yield 3-(2-(2- ...