Steroids

Lipase-catalyzed regioselective preparation of fatty acid esters of hydrocortisone

PG Quintana, A Baldessari

Index: Quintana, Paula G.; Baldessari, Alicia Steroids, 2009 , vol. 74, # 13-14 p. 1007 - 1014

Full Text: HTML

Citation Number: 20

Abstract

A series of fatty acid derivatives of hydrocortisone has been prepared by an enzymatic methodology. Nine 21-monoacyl products and one 3, 11, 17-triacetyl derivative, nine of them novel compounds, were obtained in a highly regioselective way through lipase-catalyzed esterification, transesterification and alcoholysis reactions. The influence of various reaction parameters such as acylating agent: substrate ratio, enzyme: substrate ratio, solvent, ...

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