Synthesis of a series of N 6-substituted adenosines with activity against trypanosomatid parasites

A Link, P Heidler, M Kaiser, R Brun

Index: Link, Andreas; Heidler, Philipp; Kaiser, Marcel; Brun, Reto European Journal of Medicinal Chemistry, 2009 , vol. 44, # 9 p. 3665 - 3671

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Citation Number: 6

Abstract

The involvement of purine salvage in the accumulation of current trypanocidal drugs is important for the treatment of African sleeping sickness. The substrate specificity of essential nucleoside transporters is therefore of physiological and pharmacological interest. With the intention to contribute to the knowledge in the field, a series of 16 adenosine derivatives with substituents in N6-position were prepared in order to evaluate their potential to inhibit ...