Preparation of conjugates of uridine with proteins by the imido ester condensation method
H Pischel, A Holý, G Wagner
Index: Pischel, Helmut; Holy, Antonin; Wagner, Guenther Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 4 p. 933 - 940
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Citation Number: 3
Abstract
Abstract Reaction of 5'-Op-toluenesulfonyl-2', 3'-O-isopropylideneuridine (I) with sodium 4- cyanophenoxide afforded 2', 3'-O-isopropylidene-5'-O-(4-cyanophenyl) uridine (II) which was converted by acid hydrolysis into 5'-O-(4-cyanophenyl) uridine (IIIa). Acid-catalyzed addition of ethanol to compound IIIa gave the imido ester hydrochloride IIIb which on reaction with ammonia or ethylamine was transformed into the amidine derivatives IIIc and ...
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