Transition??Metal??Free Approach to 4??Ethynylpyrimidines via Alkenynones

…, AS Pankova, MA Kuznetsov

Index: Golubev, Pavel R.; Pankova, Alena S.; Kuznetsov, Mikhail A. European Journal of Organic Chemistry, 2014 , vol. 2014, # 17 p. 3614 - 3621

Full Text: HTML

Citation Number: 2

Abstract

Abstract A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl) pent-1-en-4-yn-3-ones has been developed. As these latter ketones are easily accessible from bis (trimethylsilyl) acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%.

Related Articles:

Preparation of conjugates of uridine with proteins by the imido ester condensation method

[Pischel, Helmut; Holy, Antonin; Wagner, Guenther Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 4 p. 933 - 940]

Azide and fluoride exchange reactions of halodiazirines

[Moss, Robert A.; Terpinski, Jacek; Cox, D. Phillip; Denneey, Dorothy Z.; Krogh-Jespersen, Karsten Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2743 - 2748]

Azide and fluoride exchange reactions of halodiazirines

[Moss, Robert A.; Terpinski, Jacek; Cox, D. Phillip; Denneey, Dorothy Z.; Krogh-Jespersen, Karsten Journal of the American Chemical Society, 1985 , vol. 107, # 9 p. 2743 - 2748]

More Articles...