Synthesis of Fluorinated β-Ketosulfones and gem-Disulfones by Nucleophilic Fluoroalkylation of Esters and Sulfinates with Di-and Monofluoromethyl Sulfones

C Ni, L Zhang, J Hu

Index: Ni, Chuanfa; Zhang, Laijun; Hu, Jinbo Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 3767 - 3771

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Citation Number: 21

Abstract

An efficient and practically useful method for the preparation of α-functionalized mono-and difluoro (phenylsulfonyl) methanes by using a nucleophilic fluoroalkylation methodology was developed. α, α-Difluoro-β-ketosulfones, α-monofluoro-β-ketosulfones, and α-fluoro disulfones were successfully prepared in excellent yields by nucleophilic fluoroalkylation of esters and sulfinates with PhSO2CF2H and PhSO2CH2F reagents.