Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of …

…, JNM Commandeur, EA Worthington…

Index: Andreadou; Menge; Commandeur; Worthington; Vermeulen Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2040 - 2046

Full Text: HTML

Citation Number: 118

Abstract

Eighteen Se-substituted selenocysteine derivatives were synthesized as potential kidney selective prodrugs which can be activated by renal cysteine conjugate β-lyase to selenium- containing chemoprotectants or antitumor agents. Selenocysteine derivatives with aliphatic and benzylic Se-substituents were synthesized by reducing selenocystine to selenocysteine followed by a reaction with the corresponding alkyl and benzyl halogenides. ...