Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogs

VG DeVries, JD Bloom, MD Dutia…

Index: DeVries, Vern G.; Bloom, Jonathan D.; Dutia, Minu D.; Katocs, Andrew S.; Largis, Elwood E. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2318 - 2325

Full Text: HTML

Citation Number: 24

Abstract

The discovery that a series of N, N-dialkyl-"-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone. This study culminated in the selection of N'-(2, 4-dimethylphenyl)-N-benzyl- Nn-butylurea (1 15) for more extensive biological evaluation. ACAT inhibitors are seen as potentially beneficial agents against hypercholesterolemia and atherosclerosis.