Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2, 4-diaminoquinazoline

…, Y Han, CZ Yuan, Y Wang, ZK Xiahou, J Liao…

Index: Cao, Sheng-Li; Han, Ying; Yuan, Chong-Zhen; Wang, Yao; Xiahou, Zhi-Kai; Liao, Ji; Gao, Rui-Ting; Mao, Bei-Bei; Zhao, Bao-Li; Li, Zhong-Feng; Xu, Xingzhi European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 401 - 409

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Citation Number: 21

Abstract

A novel series of 4-substituted-piperazine-1-carbodithioate derivatives of 2, 4- diaminoquinazoline were synthesized and tested for their antiproliferative activities against five human cancer cell lines including A549 (lung cancer), MCF-7 (breast adenocarcinoma), HeLa (cervical carcinoma), HT29 and HCT-116 (colorectal cancer). Most of the synthesized compounds showed broad spectrum antiproliferative activity (IC50 1.47–11.83 μM), of ...