Structure− Activity Relationships of Highly Cytotoxic Copper (II) Complexes with Modified Indolo [3, 2-c] quinoline Ligands

…, MA Jakupec, A Roller, BK Keppler, VB Arion

Index: Primik, Michael F.; Goeschl, Simone; Jakupec, Michael A.; Roller, Alexander; Keppler, Bernhard K.; Arion, Vladimir B. Inorganic Chemistry, 2010 , vol. 49, # 23 p. 11084 - 11095

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Citation Number: 26

Abstract

Reactions of CuCl2 with indoloquinolin-6-ones modified at the lactam function resulted in five-coordinate copper (II) complexes, which remain intact in aqueous solution containing 1% DMSO over 24 h. The complexes show remarkably high antiproliferative activities in human cancer cell lines with IC50 values in the 10− 8 to 10− 6 M concentration range.