Tetrahedron Letters

Nouvelle voie de synthese d'acides amines monofluores

AI Ayi, W Remli, R Guedj

Index: Ayi, A. I.; Remli, M.; Guedj, R. Tetrahedron Letters, 1981 , vol. 22, # 16 p. 1505 - 1508

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Citation Number: 27

Abstract

Résumé Ring opening of the glycidonitriles (IIa-e) by HF/pyridine leads to the fluorocyanohydrins (IIIa-e). Treatment of the nitriles (IIIa-e) with ammonia in methanol the α- amino-β-fluoro nitriles (IVa-e) which upon acidic hydrolysis afford theβp-fluoro-α-amino acids (Va-e) in good overall yield.

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