Agents for the treatment of brain edema. 2.[(2, 3, 9, 9a-Tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl) oxy] alkanoic acids and some of their analogs

…, AM Pietruszkiewicz, C Ziegler, Y Sakurai…

Index: Cragoe; Woltersdorf; Gould; Pietruszkiewicz; Ziegler; Sakurai; Stokker; Anderson; Bourke; Kimelberg Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 825 - 841

Full Text: HTML

Citation Number: 60

Abstract

Our initial paper discussed brain edema resulting from traumatic head injury and the need for specific and effective agents to treat the disorder and disclosed a novel approach for the discovery of a drug of this kind. The current study describes the synthesis of a series of [(2, 3, 9, 9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl) oxy] alkanoic acids and their analogues. These compounds were evaluated in an in vitro cerebrocortical tissue slice ...

Related Articles:

A remarkable effect of ionic liquids in transition-metal-free aerobic oxidation of benzylic alcohols

[Oda, Yoshiro; Hirano, Koji; Satoh, Tetsuya; Kuwabata, Susumu; Miura, Masahiro Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5392 - 5394]

Direct synthesis of 1-indanones via Pd-catalyzed olefination and ethylene glycol-promoted Aldol-type annulation cascade

[Ruan, Jiwu; Saidi, Ourida; Iggo, Jonathan A.; Xiao, Jianliang Journal of the American Chemical Society, 2008 , vol. 130, # 32 p. 10510 - 10511]

Direct and efficient one-pot preparation of ketones from aldehydes using N-tert-butylphenylsulfinimidoyl chloride

[Crawford, James J.; Henderson, Kenneth W.; Kerr, William J. Organic Letters, 2006 , vol. 8, # 22 p. 5073 - 5076]

Cyanocuprates convert carboxylic acids directly into ketones

[Genna, Douglas T.; Posner, Gary H. Organic Letters, 2011 , vol. 13, # 19 p. 5358 - 5361]

Convenient processes for the synthesis of aromatic ketones from aryl bromides and carboxylic anhydrides using a cobalt catalysis

[Kazmierski, Igor; Bastienne, Mylene; Gosmini, Corinne; Paris, Jean-Marc; Perichon, Jacques Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 936 - 942]

More Articles...