Tetrahedron letters

Catalytic asymmetric Darzens condensation under phase-transfer-catalyzed conditions

S Arai, T Shioiri

Index: Arai, Shigeru; Shioiri, Takayuki Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2145 - 2148

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Citation Number: 96

Abstract

The catalytic asymmetric Darzens condensation promoted by the quaternary ammonium salt (PTC A) derived from cinchonine as a phase-transfer catalyst is described. Treatment of phenacyl chloride with various aldehydes under mild reaction conditions afforded the corresponding desired product in good yield with good to moderate enantiomeric excess.

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