Development and characterization of biphenylsulfonamides as novel inhibitors of bone resorption

…, AI Idris, SH Ralston, RJ van't Hof

Index: Greig, Iain R.; Idris, Aymen I.; Ralston, Stuart H.; Van't Hof, Rob J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7487 - 7492

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Citation Number: 16

Abstract

Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used treatments for these diseases. We have identified and characterized a series of novel biphenylsulfonamide derivatives that have potent inhibitory effects on osteoclastic bone resorption in vitro and that prevent ovariectomy-induced bone loss in vivo. A number of aromatic substituted ...