The Journal of organic chemistry

Functionalization of organotrifluoroborates: reductive amination

GA Molander, DJ Cooper

Index: Molander, Gary A.; Cooper, David J. Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3885 - 3891

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Citation Number: 37

Abstract

Herein we report the conversion of aldehyde-containing potassium and tetrabutylammonium organotrifluoroborates to the corresponding amines through reductive amination protocols. Potassium formate facilitated by catalytic palladium acetate, sodium triacetoxyborohydride, and pyridine borane have all served as effective hydride donors, reducing the initially formed imines or iminium ions to provide the corresponding amines.