The Journal of Organic Chemistry

Synthesis of peptides containing S-(N-alkylcarbamoyl) cysteine residues, metabolites of N-alkylformamides in rodents and in humans

MD Threadgill, AP Gledhill

Index: Threadgill, Michael D.; Gledhill, Adrian P. Journal of Organic Chemistry, 1989 , vol. 54, # 12 p. 2940 - 2949

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Citation Number: 48

Abstract

Hydrochloride salts of S-(N-methylcarbamoyl), S-(N-ethylcarbamoyl), and S-(Nfl- dimethylcarbamoyl) derivatives of cysteine, N-acetylcysteine, and cysteinylglycine have been prepared. S-(N-Methylcarbamoy1) glutathione hydrochloride has also been synthesized. Protecting groups for amino and carboxylic acid functions were selected for their ability to solubilize the peptides in dichloromethane in which solvent the thiols were ...

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Synthesis of peptides containing S-(N-alkylcarbamoyl) cysteine residues, metabolites of N-alkylformamides in rodents and in humans

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