Synthesis and evaluation of radioiodinated terminal para-iodophenyl-substituted. alpha.-and. beta.-methyl-branched fatty acids

MM Goodman, G Kirsch…

Index: Goodman, M. M.; Kirsch, G.; Knapp, F. F. Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 390 - 397

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Citation Number: 169

Abstract

Methods have been developed for the preparation of terminal p-iodophenyl-substituted CY- and (3-methyl-branched long-chain fatty acids. The syntheses and physical properties of 14- (p-iodophenyl)-2 (RS)-methyltetradecanoic acid and 15-p-iodophenyl)-3 (RS)- methylpentadecanoic acid are described. The radioiodinated agents are of interest as a result of the expected pronounced uptake and prolonged myocardial retention that may ...

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