Efficient synthesis of N, N-disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution in water

D Prim, G Kirsch, JF Nicoud

Index: Prim, Damien; Kirsch, Gilbert; Nicoud, Jean-Francois Synlett, 1998 , # 4 p. 383 - 384

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Citation Number: 26

Abstract

Abstract: We have developed the first synthesis of N, N-disubstituted 5-aminothiophene-2- carboxaldehydes by Nucleophilic Aromatic Substitution of 5-bromothiophene-2- carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to the corresponding imines or amino derivatives respectively.