A practical one pot synthesis of 2-[2-(pyridylmethyl)-thio]-1H-benzimidazoles

RA Rane, RK Pathak, CP Kaushik…

Index: Rane; Pathak; Kaushik; Prasad Rao; Kumar, Ashok Synthetic Communications, 2002 , vol. 32, # 8 p. 1211 - 1217

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Citation Number: 9

Abstract

ABSTRACT A combination of Et3N and p TSCl was found to be far superior than p TSCl or benzene sulfonyl chloride alone in converting substituted 2-picoline-N-oxides to the corresponding 2-chloromethylpyridines and has been exploited for the synthesis of a variety of 2-[2-(pyridylmethyl)-thio]-1H-benzimidazoles, key intermediates in the manufacture of H+/K+-ATPase inhibitors in a single pot.