Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma

…, R Malaviya, M Matheis, G Olini, D Cavender…

Index: Lagu, Bharat; Gerchak, Chrissy; Pan, Meng; Hou, Cuifen; Singer, Monica; Malaviya, Ravi; Matheis, Michele; Olini, Gil; Cavender, Druie; Wachter, Michael Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4382 - 4386

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Citation Number: 36

Abstract

A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure– activity relationships in the series are described herein along with some detailed characterization of the interesting compounds.