Total synthesis of pteridic acids A and B

…, S Fujimura, S Kuwahara

Index: Nakahata, Takashi; Fujimura, Shohei; Kuwahara, Shigefumi Chemistry - A European Journal, 2006 , vol. 12, # 17 p. 4584 - 4593

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Citation Number: 18

Abstract

Abstract Pteridic acid A (1) is a spirocyclic octaketide produced by the phytoepiphytic actinomycete Streptomyces hygroscopicus TP-A0451 and possesses potent plant-growth- promoting activity comparable to that of indole-3-acetic acid. The enantioselective total synthesis of this natural product was achieved by employing the Sn (OTf) 2-mediated Evans aldol reaction and the Fukuyama acetylenic coupling reaction as the key C [BOND] C ...