Sodium Tetramethoxyborate: An Efficient Catalyst for Michael Additions of Stabilized Carbon Nucleophiles

…, N Fuentes, E Gómez-Bengoa, C Mateo…

Index: Campana, Araceli G.; Fuentes, Noelia; Gomez-Bengoa, Enrique; Mateo, Cristina; Oltra, J. Enrique; Echavarren, Antonio M.; Cuerva, Juan M. Journal of Organic Chemistry, 2007 , vol. 72, # 21 p. 8127 - 8130

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Citation Number: 13

Abstract

Sodium tetramethoxyborate, easily prepared by reaction of inexpensive sodium borohydride with methanol, possesses a suitable combination of a Lewis base and a Lewis acid to catalyze Michael reactions at room temperature under practically neutral conditions. This reaction provides good to excellent yields of Michael addition products from a broad scope of Michael donor and Michael acceptor reagents.