General method for the synthesis of selectively N-alkylated polyamines

…, MJ Payne, MA Balk, JL Gress, FD Harris…

Index: Nordlander, J. Eric; Payne, Mark J.; Balk, Michael A.; Gress, Julia L.; Harris, Frederick D.; et al. Journal of Organic Chemistry, 1984 , vol. 49, p. 133 - 138

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Citation Number: 25

Abstract

A versatile method is presented for the synthesis of linear polyamines-in particular, the naturally ubiquitous putrescine, spermidine, and spermine-regiospecifically N-alkylated or N- polyalkylated. The new approach is based on the acylation of amines with N-(trifluoroacety1) amino acid chlorides, optional alkylation followed by selective saponification of the (trifluoroacetylhnino function, analogous reacylation, and polyamide to polyamine ...