Synthesis of γ, δ-unsaturated quaternary α-alkylamino acids using umpolung reaction and Claisen rearrangement

I Mizota, K Tanaka, M Shimizu

Index: Mizota, Isao; Tanaka, Katsuki; Shimizu, Makoto Tetrahedron Letters, 2012 , vol. 53, # 14 p. 1847 - 1850

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Citation Number: 11

Abstract

An umpolung of α-imino ester is difficult to take place due to the electronegativity of the imino functionality, 12 and therefore, only limited examples are available. 13 We have studied umpolung reactions of α-imino esters and have already reported N-alkylation-coupling reactions of the imines derived from glyoxylates. 14 and 15 Although three component coupling of α-imino esters was reported using umpolung addition of organometals, there still appears to remain an ...