Heterocycles as masked diamide/dipeptide equivalents. Formation and reactions of substituted 5-(acylamino) oxazoles as intermediates en route to the cyclopeptide …

…, RW Hungate, KE McCarthy

Index: Lipshutz, Bruce H.; Hungate, Randall W.; NcCarthy, Keith E. Journal of the American Chemical Society, 1983 , vol. 105, # 26 p. 7703 - 7713

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Citation Number: 20

Abstract

Abstract: A variety of novel 2, 4-dialkyl-5-(acylamino) oxazoles have been prepared by using either amide nitriles or diamides/dipeptides as starting materials. Ring closure calls for the use of trifluoroacetic acid/trifluoroacetic acid anhydride or an acid halide in chlorinated solvents. The first examples of chiral systems have also been prepared incorporating both alkyl and protected amine substitutents at the C-2 methyl residue derived from the ...