Synthesis and antimicrobial activities of novel series of 1-((4-methyl-2-substituted thiazol-5-yl) methyleneam INO)-2-substituted isothiourea derivatives

…, PC Mhaske, P Hande, VD Bobade

Index: Shelke, Shivaji H.; Mhaske, Pravin C.; Hande, Pankaj; Bobade, Vivek D. Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 9 p. 1262 - 1270

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Citation Number: 4

Abstract

A novel series of 1-((4-methyl-2-substituted thiazol-5-yl)methyleneamino)-2-substituted isothiourea derivatives was synthesized by alkylation of (Z/E)-1-((4-methyl-2-substituted thiazol-5-yl)methylene )thiosemicarbazide with alkylhalide in acetone. All the newly synthesized compounds were characterized by spectral (IR, 1 H NMR, 13 C NMR, and mass spectrometry) methods. The newly synthesized compounds were screened for in vitro antimicrobial activity. Most of the compounds show ...