Improved Synthesis of Fluoroalkyl and Fluoroaryl Substituted 2-Aminopyrimidines

A Kucerovy, PG Mattner, JS Hathaway…

Index: Kucerovy, Andrew; Mattner, Paul G.; Hathaway, Joel S.; Repic, Oljan Synthetic Communications, 1990 , vol. 20, # 6 p. 913 - 917

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Abstract

Abstract: Fluoroalkyl and fluoroaryl substituted 2-aminopyrimidines have been prepared in good yields by the cyclization of guanidine salts with fluorine substituted P-diketones in sodium isopropoxide/isopropanol at reflux. ... One of the most direct routes to substituted 2-aminopyrimidines is ... P-diketones. Numerous reaction conditions have been employed for carrying ... In connection with ongoing investigations of pharmaceutically interesting

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