Synthesis of 3-nitro-5-acylpyridines by condensation of sodium nitromalonaldehyde/tosyl chloride with 2-amino-1-acylolefins. Evidence for the intermediacy of 3- …

JM Hoffman, BT Phillips…

Index: Hoffman, Jacob M.; Phillips, Brian T.; Cochran, David W. Journal of Organic Chemistry, 1984 , vol. 49, # 1 p. 193 - 195

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Citation Number: 8

Abstract

pentane (0.321 g) was condensed onto an approximately equal volume of fuming sulfuric acid (30% SO3) which had been degassed and vacuum stripped to remove the SO,; the reaction tube was then sealed under vacuum and heated in a tube furnace at 360" C for 24 h. The tube was then opened on the vacuum line and the reaction mixture fractionated through-131 and-196" C cold traps, most of the material being collected in the-131" C trap. ...